Drop out of school to ride with the Merry Pranksters. Form America’s most enduring jam band. Become a family man and father. Never stop chasing the muse. Bob Weir took his own path to and through superstardom as rhythm guitarist for The Grateful Dead. Mike Fleiss re-imagines the whole wild journey in this magnetic rock doc and concert film, with memorable input from bandmates, contemporaries, followers, family, and, of course, the inimitable Bob Weir himself.

By coincidence rather then by design the swiss chemist Albert Hofmann makes a sensational discovery in the spring of 1943. He realizes that he is dealing with a powerful molecule that will have an impact not only on the scientific world. THE SUBSTANCE - is an investigation into our troubled relation with LSD. Told from its beginnings until today.